2014 / Randomized split-face histomorphology
A closer look at the collagen story.
Do tissue markers explain the visible result?
Source access: publication abstract
The study#
- Design
- Randomized split-face histomorphology
- Population
- 24 women, aged 35–45
- Follow-up / endpoint
- Biopsies at 4 and 9 months
- Source
- Journal of Drugs in Dermatology, 2014 · PMID 25226004
What the authors found#
CaHA showed greater type III collagen staining at four months and greater type I staining at nine months than the studied HA comparator.[1]
Editorial interpretation
Why it is interesting#
The sequence is consistent with matrix remodeling in the sampled tissue.
Biological activity is an evidence layer, not a substitute for clinical outcomes.
What it cannot tell us#
- Small, narrow population and postauricular biopsy sites.
- Histological markers cannot establish superior visible outcomes or safety across facial indications.
Selection for this library reflects educational interest. It is not a systematic search, formal certainty grade, or complete account of the literature.
Funding & commercial context#
Consult the publication's full text for funding and conflict-of-interest statements; the abstract does not provide a complete disclosure.
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Source & citation#
Yutskovskaya et al. — CaHA and HA histomorphology ↗Checked 2026-09-06 · Journal of Drugs in Dermatology, 2014 · PMID 25226004. Cite the original publication when discussing its results; this page is an interpretation.
Aesthetic Pass. A closer look at the collagen story. Product Atlas research interpretation 2026.09.06.1. https://aestheticpass.com/products/studies/radiesse-human-histology/