A more considered reading

Same class. Product-specific units.

Why botulinum toxin potency units, product labels and trial endpoints should remain attached to the exact formulation.

Clinical context · September 2026

A potency unit belongs to its preparation.#

BOTOX Cosmetic, Azzalure, Letybo and BOCOUTURE labeling explicitly warns against interchanging potency units across preparations. Matching a numeric dose is not evidence of matching biological activity.[1][2][3][4]

A regional name needs a regional label.#

The US BOTOX Cosmetic label includes platysma bands. That does not extend VISTABEL indications in Germany. A discovery-family link connects names; the local product information determines the cited use.[1][5]

Compare methods before response rates.#

The Letybo study used a composite patient-and-investigator endpoint. ULTRA used defined region-specific responses. Percentages across these trials do not establish dose equivalence or a treatment ranking.[6][7]

Keep preparation beside the source.#

The atlas links to the full manufacturer instructions for the actual product, including preparation, application and precautions. It deliberately does not provide a cross-brand dose converter.[1][2][4]

Explore the relevant products

Source documents

  1. [1] BOTOX Cosmetic prescribing information ↗Allergan / DailyMed · Document accessed · Checked 2026-09-06
  2. [2] Azzalure Summary of Product Characteristics ↗Galderma / emc · Document accessed · Checked 2026-09-06
  3. [3] Letybo 50 units Summary of Product Characteristics ↗Hugel / emc · Document accessed · Checked 2026-09-06
  4. [4] BOCOUTURE Summary of Product Characteristics ↗Merz / emc · Document accessed · Checked 2026-09-06
  5. [5] VISTABEL German Fachinformation ↗AbbVie / Fachinfo · Document accessed · Checked 2026-09-06
  6. [6] Mueller et al. — letibotulinumtoxinA phase III trial ↗Aesthetic Surgery Journal, 2022 · PMID 35092418 · Abstract accessed · Checked 2026-09-06
  7. [7] IncobotulinumtoxinA — ULTRA I and ULTRA II ↗Aesthetic Surgery Journal · PMID 39475143 · Abstract accessed · Checked 2026-09-06