A filler’s location inside the dermis matters.

The study#

Design

Human histology and immunohistochemistry

Population

15 participants; iliac-crest skin

Follow-up / endpoint

8 and 114 days

Source

Dermatology, 2014 · PMID 24503674

What the authors found#

Three HA formulations had different dermal distribution patterns. The polydensified formulation showed more homogeneous integration in the sampled tissue.[1]

Editorial interpretation

Why it is interesting#

Relevant as material-level context for CPM HA; exact commercial-formulation attribution needs full-text verification.

Tissue integration should inform questions, not justify an untested claim of safer facial injection.

What it cannot tell us#

• Non-facial sites and a small sample.
• The abstract does not establish that today's Balance (+) presentation is identical to the studied formulation.

Selection for this library reflects educational interest. It is not a systematic search, formal certainty grade, or complete account of the literature.

Funding & commercial context#

Consult the publication's full text for funding and conflict-of-interest statements; the abstract does not provide a complete disclosure.

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Source & citation#

Checked 2026-09-06 · Dermatology, 2014 · PMID 24503674. Cite the original publication when discussing its results; this page is an interpretation.

Aesthetic Pass. A filler’s location inside the dermis matters. Product Atlas research interpretation 2026.09.06.1. https://aestheticpass.com/products/studies/ha-tissue-integration/